Sindhu holds a B.Tech. in Electrical Engineering (1974) from the Indian Institute of Technology, Kanpur, M.S. in Electrical Engineering (1976) from the University of Hawaii, and a Ph.D (1982) in Computer Science from Carnegie Mellon University where he studied under Bob Sproull.
Sindhu had worked at the Computer Science Lab of Xerox PARC for 11 years. Sindhu worked on design tools for very-large-scale integration(VLSI) of integrated circuits and high-speed interconnects for shared memory multiprocessors.
Sindhu founded Juniper Networks along with Dennis Ferguson, and Bjorn Liencres in February 1996 in California. The company was subsequently reincorporated in Delaware on March 1998 in and went public on the 25th of June, 1999.
Sindhu was instrumental in the architecture, design, and development of the Juniper M40 data router while running the company.
Sindhu's earlier work was to subsequently influence the architecture, design, and development of Sun Microsystems' first high-performance multiprocessor system family, which includes systems such as the SS1000 and SC2000.